The Chronobiology Kit

The Chronobiology Kit is a PC hardware/software system for collecting and analyzing activity data from experimental animals. The collection system was specifically designed for the needs of circadian researchers, that is, long term data collection without interruption, on-line data verification analysis, laboratory cycle controls and automatic flagging for loss of signal.

Journal articles showing the results of using The Chronobiology Kit

1. Cavadini G, Petrzilka S, Kohler P, Jud C, Tobler I, Birchler T, et al. TNF-alpha suppresses the expression of clock genes by interfering with E-box-mediated transcription. Proc Natl Acad Sci U S A 2007;104(31):12843-8.

2. Cederroth CR, Vinciguerra M, Kühne F, Madani R, Doerge DR, Visser TJ, et al. A phytoestrogen-rich diet increases energy expenditure and decreases adiposity in mice. Environ Health Perspect 2007;115(10):1467-73.

3. Amano M, Iigo M, Sunuma T, Yamashita M, Furukawa K, Tabata M, et al. Development of new self-feeding system for mass rearing of ayu Plecoglossus altivelis altivelis under artificial and natural light-dark cycles. Fisheries Science 2007;73(4):800-7.

4. Watanabe T, Naito E, Nakao N, Tei H, Yoshimura T, Ebihara S. Bimodal clock gene expression in mouse suprachiasmatic nucleus and peripheral tissues under a 7-hour light and 5-hour dark schedule. J Biol Rhythms 2007;22(1):58-68.

5. Hauzenberger AR, Gebhardt-Henrich SG, Steiger A. The influence of bedding depth on behaviour in golden hamsters (Mesocricetus auratus). Appl Anim Behav Sci 2006;100(3-4):280-94.

6. Palchykova S, Winsky-Sommerer R, Meerlo P, Durr R, Tobler I. Sleep deprivation impairs object recognition in mice. Neurobiol Learn Mem 2006;85(3):263-71.

7. Watanabe T, Kojima M, Tomida S, Nakamura TJ, Yamamura T, Nakao N, et al. Peripheral clock gene expression in CS mice with bimodal locomotor rhythms. Neurosci Res 2006;54(4):295-301.

8. Kopp C, Ressel V, Wigger E, Tobler I. Influence of estrus cycle and ageing on activity patterns in two inbred mouse strains. Behav Brain Res 2006;167(1):165-74.

9. Canal MM, Piggins HD. Resetting of the hamster circadian system by dark pulses. Am J Physiol Regul Integr Comp Physiol 2006;290(3):R785-92.

10. Vyazovskiy VV, Ruijgrok G, Deboer T, Tobler I. Running wheel accessibility affects the regional electroencephalogram during sleep in mice. Cereb Cortex 2006;16(3):328-36.

11. van der Veen DR, Minh NL, Gos P, Arneric M, Gerkema MP, Schibler U. Impact of behavior on central and peripheral circadian clocks in the common vole Microtus arvalis, a mammal with ultradian rhythms. Proc Natl Acad Sci U S A 2006;103(9):3393-8.

12. Amano M, Iigo M, Furukawa K, Tabata M, Yamamori K. Photic and circadian regulation of self-feeding activity in ayu. Fisheries Science 2006;72(2):250-5.

13. Gebhardt-Henrich SG, Vonlanthen EM, Steiger A. How does the running wheel affect the behaviour and reproduction of golden hamsters kept as pets? Appl Anim Behav Sci 2005;95(3-4):199-203.

14. Yamaoka S, Tomita T, Imaizumi Y, Watanabe K, Hatanaka A. Effects of Plant-derived Odors on Sleep-Wakefulness and Circadian Rhythmicity in Rats. Chem Senses 2005;30 Suppl 1:i264-i265.

15. Brzezinski JAt, Brown NL, Tanikawa A, Bush RA, Sieving PA, Vitaterna MH, et al. Loss of circadian photoentrainment and abnormal retinal electrophysiology in Math5 mutant mice. Invest Ophthalmol Vis Sci 2005;46(7):2540-51.

16. Brown SA, Fleury-Olela F, Nagoshi E, Hauser C, Juge C, Meier CA, et al. The period length of fibroblast circadian gene expression varies widely among human individuals. PLoS Biol 2005;3(10):e338.

17. Masubuchi S, Kataoka N, Sassone-Corsi P, Okamura H. Mouse Period1 (mPER1) acts as a circadian adaptor to entrain the oscillator to environmental light/dark cycles by regulating mPER2 protein. J Neurosci 2005;25(19):4719-24.

18. Noble C, Mizusawa K, Tabata M. Does light intensity affect self-feeding and food wastage in group-held rainbow trout and white-spotted charr? J Fish Biology 2005;66(5):1387-99.

19. Coogan AN, Piggins HD. Dark pulse suppression of P-ERK and c-Fos in the hamster suprachiasmatic nuclei. Eur J Neurosci 2005;22(1):158-68.

20. D'Adamo P, Wolfer DP, Kopp C, Tobler I, Toniolo D, Lipp HP. Mice deficient for the synaptic vesicle protein Rab3a show impaired spatial reversal learning and increased explorative activity but none of the behavioral changes shown by mice deficient for the Rab3a regulator Gdi1. Eur J Neurosci 2004;19(7):1895-905.

21. Walz K, Spencer C, Kaasik K, Lee CC, Lupski JR, Paylor R. Behavioral characterization of mouse models for Smith-Magenis syndrome and dup(17)(p11.2p11.2). Hum Mol Genet 2004;13(4):367-78.

22. Coogan AN, Piggins HD. Circadian and photic regulation of phosphorylation of ERK1/2 and Elk-1 in the suprachiasmatic nuclei of the Syrian hamster. J Neurosci 2003;23(7):3085-93.

23. Easton A, Arbuzova J, Turek FW. The circadian Clock mutation increases exploratory activity and escape-seeking behavior. Genes Brain Behav 2003;2(1):11-9.

24. Toyota H, Dugovic C, Koehl M, Laposky AD, Weber C, Ngo K, et al. Behavioral characterization of mice lacking histamine H(3) receptors. Mol Pharmacol 2002;62(2):389-97.

25. Oishi K, Fukui H, Sakamoto K, Miyazaki K, Kobayashi H, Ishida N. Differential expressions of mPer1 and mPer2 mRNAs under a skeleton photoperiod and a complete light-dark cycle. Brain Res Mol Brain Res 2002;109(1-2):11-7.

26. Weibel L, Maccari S, Van Reeth O. Circadian clock functioning is linked to acute stress reactivity in rats. J Biol Rhythms 2002;17(5):438-46.

27. Kopp C, Albrecht U, Zheng B, Tobler I. Homeostatic sleep regulation is preserved in mPer1 and mPer2 mutant mice. Eur J Neurosci 2002;16(6):1099-106.

28. Chen WM, Naruse M, Tabata M. The effect of social interactions on circadian self-feeding rhythms in rainbow trout Oncorhynchus mykiss Walbaum. Physiol Behav 2002;76(2):281-7.

29. Chen WM, Naruse M, Tabata M. Circadian rhythms and individual variability of self-feeding activity in groups of rainbow trout Oncorhynchus mykiss (Walbaum). Aquaculture Res 2002;33(7):491-500.

30. Joseph V, Mamet J, Lee F, Dalmaz Y, Van Reeth O. Prenatal hypoxia impairs circadian synchronisation and response of the biological clock to light in adult rats. J Physiol 2002;543(Pt 1):387-95.

31. Van Reeth O, Weibel L, Olivares E, Maccari S, Mocaer E, Turek FW. Melatonin or a melatonin agonist corrects age-related changes in circadian response to environmental stimulus. Am J Physiol Regul Integr Comp Physiol 2001;280(5):R1582-91.

32. Challet E, Turek FW, Laute M, Van Reeth O. Sleep deprivation decreases phase-shift responses of circadian rhythms to light in the mouse: role of serotonergic and metabolic signals. Brain Res 2001;909(1-2):81-91.

33. Suzuki T, Ishikawa A, Yoshimura T, Namikawa T, Abe H, Honma S, et al. Quantitative trait locus analysis of abnormal circadian period in CS mice. Mamm Genome 2001;12(4):272-7.

34. Albrecht U, Zheng B, Larkin D, Sun ZS, Lee CC. MPer1 and mper2 are essential for normal resetting of the circadian clock. J Biol Rhythms 2001;16(2):100-4.

35. Abe H, Honma S, Namihira M, Masubuchi S, Honma K. Behavioural rhythm splitting in the CS mouse is related to clock gene expression outside the suprachiasmatic nucleus. Eur J Neurosci 2001;14(7):1121-8.

36. Masubuchi S, Honma S, Abe H, Nakamura W, Honma K. Circadian activity rhythm in methamphetamine-treated Clock mutant mice. Eur J Neurosci 2001;14(7):1177-80.

37. Zheng B, Albrecht U, Kaasik K, Sage M, Lu W, Vaishnav S, et al. Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock. Cell 2001;105(5):683-94.

38. Suzuki T, Ishikawa A, Nishimura M, Yoshimura T, Namikawa T, Ebihara S. Mapping quantitative trait loci for circadian behavioral rhythms in SMXA recombinant inbred strains. Behav Genet 2000;30(6):447-53.

39. Deboer T, Tobler I. Running wheel size influences circadian rhythm period and its phase shift in mice. J Comp Physiol [A] 2000;186(10):969-73.

40. Masubuchi S, Honma S, Abe H, Ishizaki K, Namihira M, Ikeda M, et al. Clock genes outside the suprachiasmatic nucleus involved in manifestation of locomotor activity rhythm in rats. Eur J Neurosci 2000;12(12):4206-14.

41. Yamamoto T, Shima T, Unuma T, Shiraishi M, Akiyama T, Tabata M. Voluntary intake of diets with varying digestible energy contents and energy sources, by juvenile rainbow trout Oncorhynchus mykiss, using self-feeders. Fisheries Science 2000;66(3):528-34.

42. Naylor E, Bergmann BM, Krauski K, Zee PC, Takahashi JS, Vitaterna MH, et al. The circadian Clock mutation alters sleep homeostasis in the mouse. J Neurosci 2000;20(21):8138-43.

43. Challet E, Kolker DE, Turek FW. Metabolic influences on circadian rhythmicity in Siberian and Syrian hamsters exposed to long photoperiods. J Neuroendocrinol 2000;12(1):69-78.

44. Weibel L, Turek FW, Mocaer E, Van Reeth O. A melatonin agonist facilitates circadian resynchronization in old hamsters after abrupt shifts in the light-dark cycle. Brain Res 2000;880(1-2):207-11.

45. Challet E, van Reeth O, Turek FW. Altered circadian responses to light in streptozotocin-induced diabetic mice. Am J Physiol 1999;277(2 Pt 1):E232-7.

46. Challet E, Losee-Olson S, Turek FW. Reduced glucose availability attenuates circadian responses to light in mice. Am J Physiol 1999;276(4 Pt 2):R1063-70.

47. Abe H, Honma S, Honma K, Suzuki T, Ebihara S. Functional diversities of two activity components of circadian rhythm in genetical splitting mice (CS strain). J Comp Physiol [A] 1999;184(3):243-51.

48. Zheng B, Larkin DW, Albrecht U, Sun ZS, Sage M, Eichele G, et al. The mPer2 gene encodes a functional component of the mammalian circadian clock. Nature 1999;400(6740):169-73.

49. Solberg LC, Horton TH, Turek FW. Circadian rhythms and depression: effects of exercise in an animal model. Am J Physiol 1999;276(1 Pt 2):R152-61.

50. Harada Y, Goto M, Ebihara S, Fujisawa H, Kegasawa K, Oishi T. Circadian Locomotor Activity Rhythms in the African Clawed Frog, Xenopus laevis: The Role of the Eye and the Hypothalamus. Biological Rhythm Research 1998;29(1):30-48.

51. Schwierin B, Borbely AA, Tobler I. Sleep homeostasis in the female rat during the estrous cycle. Brain Res 1998;811(1-2):96-104.

52. Challet E, Scarbrough K, Penev PD, Turek FW. Roles of suprachiasmatic nuclei and intergeniculate leaflets in mediating the phase-shifting effects of a serotonergic agonist and their photic modulation during subjective day. J Biol Rhythms 1998;13(5):410-21.

53. Van Reeth O, Olivares E, Turek FW, Granjon L, Mocaer E. Resynchronisation of a diurnal rodent circadian clock accelerated by a melatonin agonist. Neuroreport 1998;9(8):1901-5.

54. Sánchez-Vázquez FJ, Tabata M. Circadian rhythms of demand-feeding and locomotor activity in rainbow trout. J Fish Biology 1998;52(2):255-67.

55. Challet E, Solberg LC, Turek FW. Entrainment in calorie-restricted mice: conflicting zeitgebers and free-running conditions. Am J Physiol 1998;274(6 Pt 2):R1751-61.

56. Penev PD, Kolker DE, Zee PC, Turek FW. Chronic circadian desynchronization decreases the survival of animals with cardiomyopathic heart disease. Am J Physiol 1998;275(6 Pt 2):H2334-7.

57. Labyak SE, Turek FW, Wallen EP, Zee PC. Effects of bright light on age-related changes in the locomotor activity of Syrian hamsters. Am J Physiol 1998;274(3 Pt 2):R830-9.

58. Yoshimura T, Ebihara S. Decline of circadian photosensitivity associated with retinal degeneration in CBA/J-rd/rd mice. Brain Res 1998;779(1-2):188-93.

59. Reierth E, Stokkan KA. Dual entrainment by light and food in the Svalbard ptarmigan (Lagopus mutus hyperboreus). J Biol Rhythms 1998;13(5):393-402.

60. Reierth E, Stokkan K. Activity rhythm in high artic Svalbard ptarmigan (Lagopus mutus hyperboreus). Can J Zool 1998;76:2031-9.

61. Cordoba J, Dupuis J, Gottstein J, Blei AT. Stenosis of a portacaval anastomosis affects circadian locomotor activity in the rat: a multivariable analysis. Am J Physiol 1997;273(6 Pt 1):G1218-25.

62. Scarbrough K, Losee-Olson S, Wallen EP, Turek FW. Aging and photoperiod affect entrainment and quantitative aspects of locomotor behavior in Syrian hamsters. Am J Physiol 1997;272(4 Pt 2):R1219-25.

63. Van Reeth O, Olivares E, Zhang Y, Zee PC, Mocaer E, Defrance R, et al. Comparative effects of a melatonin agonist on the circadian system in mice and Syrian hamsters. Brain Res 1997;762(1-2):185-94.

64. Antoch MP, Song EJ, Chang AM, Vitaterna MH, Zhao Y, Wilsbacher LD, et al. Functional identification of the mouse circadian Clock gene by transgenic BAC rescue. Cell 1997;89(4):655-67.

65. Valentinuzzi VS, Scarbrough K, Takahashi JS, Turek FW. Effects of aging on the circadian rhythm of wheel-running activity in C57BL/6 mice. Am J Physiol 1997;273(6 Pt 2):R1957-64.

66. Lopez-Molina L, Conquet F, Dubois-Dauphin M, Schibler U. The DBP gene is expressed according to a circadian rhythm in the suprachiasmatic nucleus and influences circadian behavior. Embo J 1997;16(22):6762-71.

67. Penev PD, Turek FW, Wallen EP, Zee PC. Aging alters the serotonergic modulation of light-induced phase advances in golden hamsters. Am J Physiol 1997;272(2 Pt 2):R509-13.

68. Penev PD, Zee PC, Turek FW. Quantitative analysis of the age-related fragmentation of hamster 24-h activity rhythms. Am J Physiol 1997;273(6 Pt 2):R2132-7.

69. Steindl PE, Coy DL, Finn B, Zee PC, Blei AT. A low-protein diet ameliorates disrupted diurnal locomotor activity in rats after portacaval anastomosis. Am J Physiol 1996;271(4 Pt 1):G555-60.

70. Zhang Y, Takahashi JS, Turek FW. Critical period for cycloheximide blockade of light-induced phase advances of the circadian locomotor activity rhythm in golden hamsters. Brain Res 1996;740(1-2):285-90.

71. Ebihara S, Mano N, Kurono N, Komuro G, Yoshimura T. Vitamin B12 affects non-photic entrainment of circadian locomotor activity rhythms in mice. Brain Res 1996;727(1-2):31-9.

72. Yoshimura T, Ebihara S. Spectral sensitivity of photoreceptors mediating phase-shifts of circadian rhythms in retinally degenerate CBA/J (rd/rd) and normal CBA/N (+/+)mice. J Comp Physiol [A] 1996;178(6):797-802.

73. Colecchia EF, Penev PD, Zee PC, Turek FW. Phase-shifting effects of a serotonin agonist in tau mutant hamsters. Brain Res 1996;730(1-2):227-31.

74. Tobler I, Gaus SE, Deboer T, Achermann P, Fischer M, Rulicke T, et al. Altered circadian activity rhythms and sleep in mice devoid of prion protein. Nature 1996;380(6575):639-42.

75. Steindl PE, Gottstein J, Blei AT. Disruption of circadian locomotor activity in rats after portacaval anastomosis is not gender dependent. Hepatology 1995;22(6):1763-8.

76. Penev PD, Zee PC, Wallen EP, Turek FW. Aging alters the phase-resetting properties of a serotonin agonist on hamster circadian rhythmicity. Am J Physiol 1995;268(1 Pt 2):R293-8.

77. Penev PD, Turek FW, Zee PC. A serotonin neurotoxin attenuates the phase-shifting effects of triazolam on the circadian clock in hamsters. Brain Res 1995;669(2):207-16.

78. Yoshimura T, Nishio M, Goto M, Ebihara S. Differences in circadian photosensitivity between retinally degenerate CBA/J mice (rd/rd) and normal CBA/N mice (+/+). J Biol Rhythms 1994;9(1):51-60.

79. Penev PD, Zee PC, Turek FW. Monoamine depletion blocks triazolam-induced phase advances of the circadian clock in hamsters. Brain Res 1994;637(1-2):255-61.

80. Vitaterna MH, King DP, Chang AM, Kornhauser JM, Lowrey PL, McDonald JD, et al. Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science 1994;264(5159):719-25.

81. Penev PD, Turek FW, Zee PC. Monoamine depletion alters the entrainment and the response to light of the circadian activity rhythm in hamsters. Brain Res 1993;612(1-2):156-64.

82. Coy DL, Mehta R, Zee P, Salchli F, Turek FW, Blei AT. Portal-systemic shunting and the disruption of circadian locomotor activity in the rat. Gastroenterology 1992;103(1):222-8.

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Last Changed: 27 August 2010